ILE, established in 1996, founded itself a provider of advanced polymeric film coating systems and technical supports for pharmaceutical and nutritional industries. Since its establishment, ILE has been engaging in R&D, manufacturing, supplying pharmaceutical excipients and business related. With its well-rounded technologies, high quality products, well technical service, ILE has been developing steadily, and its products enjoy great popularity in domestic and international markets.

At present, ILE’s products cover complete series of ready-mixed film coatings including EASPRAY ^TM immediate release film coating systems, EASCOL ^TM enteric film coating systems and EASTROL ^TM sustained release film coating systems, Crosscarmellose Sodium etc; Furthermore, ILE exclusively distributes Cellulose Ethers products of US Ashland Aqualon Functional Ingredients for Pharmaceutical and Nutritional markets in China.

Also, ILE, an ISO 9001:2000 certified company, knows very well that quality is the root and life of the company. ILE sets up the Quality management System in compliance with ISO 9000 standards and cGMP medicine management regulation. The manufacturing facilities complied with the cGMP and HACCP Standards, the professional technical support laboratory, and the professionals on production, quality, technology and management, all these guarantee the high quality products and services of ILE. Furthermore, ILE holds trainings, seminars and forums termly to share its expertise with the customers.

Through our innovative technologies and products, and with the professional technical service, we are committed to meeting the demands of our customers at every step. ILE like excellence and everyone in ILE is in practice with a commitment that “I Like Excellence”.

 Details: At present, ILE’s products cover complete series of ready-mixed film coatings including EASPRAY ^TM immediate release film coating systems, EASCOL ^TM enteric film coating systems and EASTROL ^TM sustained release film coating systems, Crosscarmellose Sodium etc; Furthermore, ILE exclusively distributes Cellulose Ethers products of US Ashland Aqualon Functional Ingredients for Pharmaceutical and Nutritional markets in China.

EASPRAY ^TM immediate release film coating systems

EASPRAY™ series is a pH independent ready to use coating material directly used in tablets, capsules, droplets, Dripping pills and pellets. Each specific formula is made up of optimally proportional film-forming materials, plasticizers, inorganic pigments and surfactants.

EASPRAY™ for Nutritionals and Foods

Nowadays, not only the pharmaceutical solid dosage forms have coating requirements, but also the health foods. The most essential properties of health foods are nutrition and safety. So we employ safe film-forming materials through strict selecting, process controlling and testing to design EASPRAY^TM Nutritional coatings. EASPRAY™ Nutritional coatings meet the requirements of “General Standard for Health Foods”. All types with different functions under EASPRAY^TM can be formulated specifically for your application and satisfy your coating requirements on health foods.

Main Types of EASPRAY^TM

EASPRAY ^TM Regular Type GAI&GAIV

EASPRAY ^TM Efficient Type GMI

EASPRAY ^TM Moisture Barrier Type GAII

EASPRAY ^TM For Nutritionals and Foods

EASCOL™ Enteric Film Coating Systems

EASCOL™ series is the kind of PH dependent polymeric coating materials which are used for enteric coatings.

Main Features

1. Polymeric membrane can keep integrated under a physiological environment with a low pH value (such as gastric fluids), which effectively prevent drug release;

2. When drug entering into a high pH value environment (such as small intestine), the film is able to dissolve fast as per the time and position planed, and rapidly release the drug.

3. Be able to coat the hydrophilic tablets or tablets with acid-sensitive ingredients.

4. Effectively improves the appearance and stomach-resistance properties of the dosage forms, meanwhile, decreases the possibility of cracking.

5. In the coating process, the coating suspension is not easy to sedimentation and is of good leveling property.

6. Superior adhesion between membrane and tablet core.

7. Various colors available; and the colors are bright and stable.

Main Formulas under EASCOL

EASCOL ^TM EOQL55

EASCOL ^TM EOBS68

EASCOL ^TM EABL55                                                                                               

EASTROL™ Sustained Release Coating Systems

EASTROL™ Sustained Release Coatings (Aqueous Ethyl Cellulose Dispersion) is one of the most popular aqueous polymeric dispersion which classified as pseudo-latex to prepare the sustained release oral dosage forms by film-controlling. It forms a coating film that of sustained release function, which makes the dosage forms release the drug continuously. At the same time, maintain an effective drug concentration during a long period so as to prolong the curative effects.

Main Features

1.     Aqueous solvents system without organic solvents

2.     High concentration and low viscosity

3.     Perfect operation properties

4.     Better Suitability

Main Formulas under EASTROL^TM

EASTROL ^TM RA (Professional Type)

EASTROL^TM – RS (Regular Type)

Croscarmellose Sodium

Croscarmellose Sodium is the sodium salt of a cross-linked, partly O-(carboxymethylated) cellulose (about 70% of the carboxyl group is sodium-type), due to the presence of crosslinks, it is not soluble in water, can absorb water several times of their own weight and become expansion rather than soluble, with good disintegration. A superior tablet and capsule disintegrator, especially fit for immediate release oral dosage forms, such as dispersion tablets, orally disintegrating tablets, rapid-release tablets.

Klucel ^TM Hydroxy Propyl Cellulose (HPC)

Klucel ^TM hydroxypropylcellulose (HPC) provides a remarkable set of physical properties for tablet binding, modified release and film coating. It combines organic solvent or aqueous solubility, thermoplasticity and surface activity.  Low viscosity E and L types are widely used for premier tablet binding with low use levels (2-6%) and improved adhesion and flexible coating applications. Regular particle size materials are used in wet processing and the X-grind material for dry processing. Many viscosity types are used for modified release matrix systems. Low molecular weight Klucel ^TM HPC polymers, due to their thermoplastic behavior and superior flow properties, find applications in melt extrusion. The PHARM grades of Klucel ^TM HPC comply with the monograph requirements of the National Formulary, European Pharmacopoeia and the Japanese Pharmacopoeia.

Benecel ^TM Hypromellose (HPMC)

Benecel ^TM Hypromellose (HPMC) is widely used in the pharmaceutical industry due to their ability to thicken, bind and retain water; emulsify; suspend particulates;stabilize; and form films. All Benecel ^TM products labeled with the PH suffix are compliant with the monograph requirements of the current editions of the National Formulary, the European Pharmacopoeia and the Japanese Pharmacopoeia.

Natrosol ^TM Hydorxy Ethyl Cellulose (HEC)

Natrosol ^TM hydroxyethylcellulose (HEC) is a non-ionic water-soluble cellulose ether. Natrosol ^TM HEC is easily dispersed in cold or hot water to give solutions of varying viscosities and desired properties, though insoluble in organic solvents. It is used in (a) solutions and gels, to control rheology, providing thickening and pseudoplasticity, (b) emulsions, for high salt tolerance and surfactant compatibility, (c) modified release matrix tablets where high-viscosity grades provides effective diffusion limiting release of drugs with low water solubility and (d) tablet coating where low viscosity grades impart flexibility to films while providing a good barrier to water and oxygen transmission. The PHARM grades of Natrosol ^TM HEC comply with the monograph requirements of the National Formulary and the European Pharmacopoeia.

Aqualon ^TM & Blanose ^TM Carboxy Methyl Cellulose (CMC)

Aqualon ^TM & Blanose ^TM Carboxymethylcellulose (CMC) is an anionic, water-soluble polymer. Typical uses for CMC are in (a) ointments, creams, and lotions, as a stabilizer, thickener and film-former,(b) jellies and salves, as a thickener, gelling agent, and protective colloid and film-former, (c) syrups and suspensions, as a thickener and suspending aid, (d) bulk laxatives, physiologically inert with high water-binding capacity, (e) muco adhesives for its absorbency, (f) sustained release, as a thickener and diffusion barrier, and (g) tablet coating as a film-former. A variety of CMC grades are available, with varying degrees of substitution, viscosities and particle sizes. S-types provide smooth solutions, based on uniform substitution. O-types provide solubility and viscosity stability on storage in low pH media.

Aqualon ^TM CMC grades designated P or PH are compliant with the monograph requirements of the United States Pharmacopoeia / National Formulary.

Blanose ^TM CMC grades designated P or PH are compliant with the monograph requirements of the European Pharmacopoeia and the United States Pharmacopoeia /National Formulary.

Aqualon ^TM Ethyl Cellulose (EC)

Aqualon ^TM Ethyl Cellulose (EC) is soluble in a wide range of organic solvents. Typically, EC is used as a non-swellable, insoluble component in matrix or coating systems. EC can be used to coat one or more active ingredients of a tablet to prevent them from reacting with other materials or with one another. It can prevent discoloration of easily oxidizable substances such as ascorbic acid, allowing granulations for easily compressed tablets and other dosage forms. EC can be used on its own or in combination with water-soluble components to prepare sustained release film coatings that are frequently used for the coating of micro-particles, pellets and tablets. The improved compressible grade, Aqualon ^TM T10 EC, was developed with optimized compactibility (high ethoxyl content and low viscosity) and good powder flow (eliminating fine particle size via micronization). The PHARM grades of Aqualon ^TM EC are compliant with the monograph requirements of the United States Pharmacopoeia/ National Formulary and the European Pharmacopoeia.