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Medicated chewing gum may prevent motion sickness
- Publisher：
- Publication：2012/10/23
Scientists in Iran have managed to overcome the unpleasant taste of the drug dimenhydrinate and developed a novel medicated chewing gum that could help to treat motion sickness.
The team wanted to incorporate dimenhydrinate - an over-the-counter motion sickness remedy - into a chewing gum that would enable the treatment to be absorbed rapidly via the buccal cavity.
Unfortunately, the unpleasant taste of many medicines - dimenhydrinate included - acts as a barrier to this method of delivery, but excipients can often be used to improve their flavour.
Now, researchers at the Islamic Azad University School of Pharmaceutical Sciences have succeeded in masking the taste of dimenhydrinate and have developed a prototype gum with an acceptable flavour profile.
Presenting the findings at the annual meeting of the American Association of Pharmaceutical Scientists in Chicago, lead researcher Mohsen Sadatrezaei said: "The main challenge in delivering drugs through chewing gum is masking the bitter taste of its active ingredient.
"We have formulated dimenhydrinate as chewing gum with acceptable taste and sensory attributes.